Leflunomide side effects, toxicity

What are the possible Leflunomide side effects, liver and heart possible problems, Leflunomide toxicity and allergic reactions, side effects.




Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using leflunomide and call your doctor at once if you have any of these serious side effects:

  • fever, chills, body aches, flu symptoms
  • white patches or sores inside your mouth or on your lips
  • chest pain
  • cough, trouble breathing (you may also have a fever)
  • pain or burning when you urinate
  • pale skin, easy bruising or bleeding, unusual weakness
  • nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash

Less serious side effects may include:

  • weakness
  • nausea, stomach pain, diarrhea, loss of appetite
  • weight loss
  • headache, dizziness
  • numbness or tingling
  • sore throat, runny or stuffy nose; or
  • mild itching or skin rash

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.











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