The price rating is based on the medium wholesale price for Estro-Span 40 (Estradiol) . The medium wholesale price is the recommended selling price. Insurance companies often use this price as the basis for Estro-Span 40 (Estradiol) reimbursement. This cost does not indicate what you would pay for Estro-Span 40 (Estradiol) if covered by your prescription benefit plan. Dollar signs are used to reflect the following price ranges: $ = < $25, $$ = $25 to $49, $$$ = $50 to $99, $$$$ = $100 to $199, and $$$$$ = > $200.