Sertraline interactions

Includes Sertraline interactions, drugs that can interact with Sertraline. What other drugs can affect , Sertraline interaction.


Talk to your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others. Taking any of these drugs with sertraline may cause you to bruise or bleed easily.

Before taking sertraline, tell your doctor if you are using any of the following medicines:

  • tramadol (Ultram, Ultram ER, Ultracet)
  • digitoxin (Crystodigin)
  • phenytoin (Dilantin), valproate (Depacon, Depakene)
  • lithium (Lithobid, Eskalith)
  • a blood thinner such as warfarin (Coumadin)
  • any other antidepressants such as amitriptyline (Elavil), citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (Tofranil), nortriptyline (Pamelor), or paroxetine (Paxil)
  • almotriptan (Axert), frovatriptan (Frova), sumatriptan (Imitrex), naratriptan (Amerge), rizatriptan (Maxalt), or zolmitriptan (Zomig); or
  • heart rhythm medication such as flecainide (Tambocor), propafenone (Rhythmol), and others

If you are using any of these drugs, you may not be able to use sertraline, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect sertraline. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.







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