Taking Actoplus Met (Metformin Pioglitazone) during pregnancy, allergy warnings

Some people have developed a life-threatening condition called lactic acidosis while taking metformin and pioglitazone. Get emergency medical help if you have any of these symptoms of lactic acidosis: weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting.

You may be more likely to develop lactic acidosis if you have congestive heart failure.

Do not use metformin and pioglitazone if you have kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Before taking this medication, tell your doctor if you have:

• congestive heart failure or heart disease
• a history of heart attack or stroke
• liver disease; or
• eye problems caused by diabetes

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

Some women using metformin and pioglitazone have started having menstrual periods, even after not having a period for a long time due to a medical condition. You may be able to get pregnant if your periods restart. Talk with your doctor about the need for birth control.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether metformin and pioglitazone passes into breast milk or if it could harm a nursing baby. Do not take metformin and pioglitazone without telling your doctor if you are breast-feeding a baby.

Older adults may have a higher risk of developing lactic acidosis. Talk with your doctor about your individual risk.

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