Actoplus Met (Metformin Pioglitazone) side effects, toxicity

Get emergency medical help if you have any of these symptoms of lactic acidosis: weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting.

Stop using metformin and pioglitazone and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• feeling short of breath, even with mild exertion
• swelling or rapid weight gain; or
• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)

Less serious side effects may include:

• sneezing, runny nose, cough or other signs of a cold
• dizziness
• headache
• mild nausea, vomiting, diarrhea, stomach pain; or
• joint or muscle pain

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

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